The tumor invades the uterine wall but through less than half of its thickness.
Standard Treatment The abdominal removal of the uterus , both tubes and ovaries and sampling the pelvic and para-aortic lymph nodes is all that is required under certain conditions—namely, that the tumor is Grade 1 or 2, involves the upper two-thirds of the uterus, does not invade the blood vessels of the uterus and invades the wall of the uterus by less than half of its thickness.
If the tumor (any grade) invades more than one-half of the uterine wall or significantly invades the blood vessels, external beam radiation therapy is usually given to the pelvis and upper vagina after surgery. The total dose is 4,000 to 5,000 cGy, given daily in divided doses, five days a week for four to five weeks.
Five-Year Survival Up to 80 percent
Investigational
• The most significant study in progress is whether postoperative pelvic radiation therapy improves survival.
• Studies are looking at the role of adjuvant chemotherapy with doxorubicin , mitoxantrone , cisplatin ,
cyclophosphamide , carboplatin and progestational hormones in various doses and regimens.
